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| Peter Scheiffele has been a Professor for Cell and Developmental Neurobiology at the Bioxentrum Basel since 2008. The main goal of his research is to reach a cell biological understanding of the cell-cell interactions and signaling events that control the formation of precise neuronal circuits during CNS development. Peter grew up in West-Berlin, Germany. He studied biochemistry at the Freie Universität Berlin and completed a diploma thesis in the laboratory of Erich Lanka at the Max-Planck Institute in Berlin-Dahlem. His interest in cell biology developed when he was a summer student in the lab of Peter Walter at UCSF in 1992. After receiving his diploma from the Freie Universität in 1994, he joined the lab of Kai Simons in the Cell Biology Programme at the European Molecular Laboratories in Heidelberg completing his Ph.D. in 1998. Peter's thesis research was focused on sorting signals that direct secreted and membrane proteins to the apical membrane of polarized epithelial cells. For his postdoctoral research Peter decided to move into neurobiology with the goal of applying cell biological approaches to the problem of CNS synapse formation. He pursued this work initially in Tito Serafini's group at the University of California at Berkeley and then continued as a guest in Marc Tessier-Lavigne's lab at the University of California San Francisco. From 2001-2008 Peter was an Assistant Professor in the Department of Physiology and Cellular Biophysics and the Center for Neurobiology & Behavior at Columbia University. CV Education 1994 B.Sc. Freie Universität Berlin , Germany 1998 Ph.D. EMBL Heidelberg, Germany Research Experience 2008 - 2001-2008
1999-2001 Postdoctoral Fellow with Tito Serafini and Marc Tessier-Lavigne. Development of cellular assays for the analysis of molecular mechanisms of neuronal synapse formation. Characterization of synapse-inducing activity of Neuroligins. 1994-1998European Molecular Biology Laboratories, Heidelberg, Germany Graduate Student with Kai Simons. Analysis of mechanisms of apical membrane trafficking in polarized epithelial cells with focus on lipid raft domains and N-glycosylation as sorting determinants. 1993-1994 Distinctions
Publications J Kim, SY Jung, YK Lee, S Park, JS Choi, CJ. Lee, YB Choi, P Scheiffele, CH. Bailey, ER. Kandel, and J-H Kim. Neuroligin-1 stabilizes NMDARs for expression of LTP and associative fear memory in the amygdala of adult animals. Proceedings of the National Academy of Sciences USA, 2008; in press. ZJ. Huang and P Scheiffele. GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development. Current Opinion in Neurobiology, 2008; in press. J Koehnke, X Jin, N Trbovic, PS. Katsamba, J Brasch, G Ahlsen, P Scheiffele, B Honig, AG. Palmer III and L Shapiro. Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure. 2008; 16(3):410-21. J Koehnke, X Jin, EC. Budreck, S Posy, P Scheiffele, B Honig, L Shapiro. Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proceedings of the National Academy of Sciences USA, 2008; 105(6):1873-8. S Gascon, J Paez-Gomez, M Diaz-Guerra, P Scheiffele, F G. Scholl. Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons. Journal of Neuroscience Methods, 2008; 168(1):104-12. AA. Beg, J Sommer, J H. Martin, and P Scheiffele. Alpha2-chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron, 2007; 55:768-778. K Futai, MJ Kim, T Hashikawa, P Scheiffele, M Sheng, Y Hayashi. Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nature Neuroscience, 2007; 10:186-19. H Taniguchi, L Gollan, F Gomez Scholl, V Mahadomrongkul, E Dobler, N Limthong, M Peck, C Aoki, P Scheiffele. Silencing of neuroligin function by postsynaptic neurexins. The Journal of Neuroscience, 2007; 27:2815-2824. T Biederer and P Scheiffele. Mixed culture assays for analyzing neuronal synapse formation. Nature Protocols; 2007; 2(3):670-676. E Budreck and P Scheiffele. Neuroligin-3 is an adhesion protein at GABAergic and glutamatergic synapses. European Journal of Neuroscience, 2007; 26(7):1738-48. B Chih, L Gollan, P Scheiffele, 2006. Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex. Neuron 51:171-8. A Beg, P Scheiffele, 2006. Neuroscience. SUMO wrestles the synapse. Science 311:962-3.
P Buttery, A Beg, B Chih, A Broder, CA Mason, P Scheiffele, 2006. The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. Proceedings of the National Academy of Sciences of the United States of America 103:1924-9.
C. Rosales, K. Osborne, G. Zuccarino, P. Scheiffele, M. Silverman, 2005. A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons. The European Journal of Neuroscience 22:2381-6. B. Chih, H. Engelman, P. Scheiffele, 2005. Control of excitatory and inhibitory synapse formation by neuroligins. Science, 307(5713):1324-8. P. Washbourne, A. Dityatev, P. Scheiffele, T. Biederer, J.A. Weiner, K. Christopherson, and Alaa El-Husseini, 2004. Cell Adhesion Molecules in Synapse Formation. The Journal of Neuroscience, 24:9244-9249 . C. Dean and P. Scheiffele, 2004. Imaging synaptogenesis by measuring the accumulation of synaptic proteins in transfected primary neurons. In: Imaging Neurons, editors: Yuste, Lanni, Konnerth, CSHL Press, 2nd edition. A. Kalinovsky and P. Scheiffele, 2004. Transcriptional control of synaptic differentiation by retrograde signals. Current Opinion in Neurobiology, 14:272-279. B. Chih, S. K. Afridi, L. Clark, P. Scheiffele, 2004. Disorder-associated mutations lead to functional inactivation of neuroligins. Human Molecular Genetics 13:1471-7. C. Dean*, F. G. Scholl*, J. Choih, J. Berger, E. Isacoff, and P. Scheiffele, 2003. Neurexin mediates the assembly of presynaptic terminals. Nature Neuroscience 6:708-716. P. Scheiffele, 2003. Cell-cell signaling during synapse formation in the CNS. Annual Reviews in Neuroscience 26:485-508 F. G. Scholl and P. Scheiffele, 2003. Making connections: Cholinesterase domain proteins in the central nervous system. Trends in Neurosciences, 26:618-624. B. Chih and P. Scheiffele, 2003. Is Reelin the answer to NMJ synapse elimination? Science STKE, pe45 (2003). E. Díaz, Y. Ge, Y.H. Yang, K.C. Loh, T.A. Serafini, Y. Okazaki, Y. Hayashizaki, T.P. Speed, J. Ngai, and P. Scheiffele, 2002. Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron 36:417-434. L. Breuza, S. Corby, J.-P. Arsanto, M.-H. Delgrossi, P. Scheiffele, and A. Le Bivic, 2002. The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. The Journal of Cell Science 115:4457-4467. P. Scheiffele, J. Fan, J. Choih, R. Fetter, and T.A. Serafini, 2000. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101: 657-669. P. Scheiffele and J. Füllekrug, 2000. Glycosylation and protein transport. Essays in Biochemistry, vol.36, edited by Philip Bernstein, Portland Press, page 27-35. T. Harder and P. Scheiffele, 2000. Regulation of raft architecture. Protoplasma, Nr. 212 / 1-2, 2000. K. Brückner*, J.P. Labrador*, P. Scheiffele*, A. Herbst*, P.H. Seeburg, and R. Klein, 1999. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22:511-524. P. Scheiffele and K. Simons, 1999. Epithelial Polarity and Sorting. in: "Epithelial morphogenesis in development and disease" edited by C. Birchmeier and W. Birchmeier, Harwood Academic Publishers, p.41-71. P. Scheiffele, A. Rietveld, T. Wilk, and K. Simons, 1999. Influenza viruses select ordered lipid domains during budding from the plasma membrane. The Journal of Biological Chemistry 274: 2038-2044. J. Füllekrug*, P. Scheiffele*, and K. Simons, 1999. VIP36 localization to the early secretory pathway. The Journal of Cell Science 112: 2813-2821. T. Harder*, P. Scheiffele*, P. Verkade, and K. Simons, 1998. Lipid-domain structure of the plasma membrane revealed by patching of membrane components. The Journal of Cell Biology 141: 929-942. P. Scheiffele, P. Verkade, A.M. Fra, H. Virta, K. Simons, and E. Ikonen, 1998. Caveolin-1 and -2 in the exocytic pathway of MDCK cells. The Journal of Cell Biology 140: 795-806. P. Scheiffele and K. Simons, 1998. Mechanisms of virus budding from the plasma membrane. Nobelsymposium NS106 on “Intracellular and persistent infections, Elsevier. P. Scheiffele, M.G. Roth, and K. Simons, 1997. Interaction of influenza virus hemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. The EMBO Journal 16:5501-5508. A. Shevchenko, P. Keller, P. Scheiffele, M. Mann, and K. Simons, 1997. Identification of components of trans-Golgi network-derived transport vesicles and detergent-insoluble complexes by nanoelectrospray tandem mass spectrometry. Electrophoresis 18:2591-2600. P. Scheiffele, J. Peränen, and K. Simons, 1995. N-glycans as apical sorting signals in epithelial cells. Nature 378:96-98. P. Scheiffele, W. Pansegrau, and E. Lanka, 1995. Initiation of Agrobacterium tumefaciens T-DNA processing. The Journal of Biological Chemistry 270:1269-76. |
